Christina Castellani
Assistant Professor
Papers
- Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma. Brain pathology (Zurich, Switzerland) e70115 (2026).
- EpigeneticAgePipeline: An R Package for Comprehensive Assessment of Epigenetic Age Metrics From Methylation Microarrays. Bioinformatics and biology insights 20, 11779322261433665 (2026).
- Plant-based dietary patterns are associated with slower epigenetic aging. Aging 18, 138-158 (2026).
- Transcriptomic analysis of cells following decreased mitochondrial DNA-copy number reveals compensatory mechanisms in mitochondrial DNA replication and cellular energetics. Experimental cell research 458, 114951 (2026).
- Viral mimicry acts as a tumor suppressor in colitis. Nature communications 17, 1313 (2026).
- Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome. Epigenomics 18, 27-44 (2026).
- Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy. Nature communications 16, 10962 (2025).
- Transcriptomic analysis of cells following decreased mitochondrial DNA-copy number reveals compensatory mechanisms in mitochondrial DNA replication and cellular energetics. bioRxiv : the preprint server for biology (2025).
- Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases. Aging cell 24, e70279 (2025).
- Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target. Scientific reports 15, 20418 (2025).
- Correction: Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging. BMC research notes 18, 197 (2025).
- Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling. Mitochondrion 84, 102042 (2025).
- Epigenome-wide Association Analysis of Mitochondrial Heteroplasmy Provides Insight into Molecular Mechanisms of Disease. medRxiv : the preprint server for health sciences (2024).
- Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome. bioRxiv : the preprint server for biology (2024).
- Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging. BMC research notes 17, 21 (2024).
- Decoding mitochondrial-nuclear (epi)genome interactions: the emerging role of ncRNAs. Epigenomics 15, 1121-1136 (2023).
- Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia. Twin research and human genetics : the official journal of the International Society for Twin Studies 26, 280-289 (2023).
- Mitochondrial genomic integrity and the nuclear epigenome in health and disease. Frontiers in endocrinology 13, 1059085 (2022).
- Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensors. Physiological genomics 54, 305-315 (2022).
- Circular RNA mediated gene regulation in chronic diabetic complications. Scientific reports 11, 23766 (2021).
- Epigenome-wide association study of mitochondrial genome copy number. Human molecular genetics 31, 309-319 (2021).
- Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease. Genome research 31, 349-358 (2021).
- Postzygotic Somatic Mutations in the Human Brain Expand the Threshold-Liability Model of Schizophrenia. Frontiers in psychiatry 11, 587162 (2020).
- Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs. Genome medicine 12, 84 (2020).
- Mitochondrial DNA copy number and incident atrial fibrillation. BMC medicine 18, 246 (2020).
- Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease. Mitochondrion 53, 214-223 (2020).
- Mitochondrial DNA Copy Number and Incident Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 141, 1823-1825 (2020).
- Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder. Journal of neurodevelopmental disorders 12, 15 (2020).
- High-Risk, High-Reward Genetics in ASD. Neuron 105, 407-410 (2020).
- Evaluation of mitochondrial DNA copy number estimation techniques. PloS one 15, e0228166 (2020).
- Association Between HIV Infection and Mitochondrial DNA Copy Number in Peripheral Blood: A Population-Based, Prospective Cohort Study. The Journal of infectious diseases 219, 1285-1293 (2019).
- Association between mitochondrial DNA copy number and sudden cardiac death: findings from the Atherosclerosis Risk in Communities study (ARIC). European heart journal 38, 3443-3448 (2017).
- VarScan2 analysis of de novo variants in monozygotic twins discordant for schizophrenia. Psychiatric genetics 27, 62-70 (2017).